After coming to Stanford in 1989 as a postdoctoral fellow, Professor Giaccia was promoted to Assistant Professor in 1992 and subsequently made the important discovery that the low oxygen microenvironment of solid tumors acted as a selective pressure for the expansion of tumor cell variants that were highly aggressive due to the loss of the p53 or PTEN tumor suppressor genes. These studies provide insight into the role of the tumor microenvironment on tumor evolution, and why solid tumors are resistant to chemotherapy and radiotherapy. Professor Giaccia has identified a number
of critical genes that are regulated by the VHL tumor suppressor gene and enhance the metastatic spread of tumor cells. Professor Giaccia is the PI of an NIH Program Project Grant that is based on developing new strategies to exploit the tumor microenvironment. His laboratory has developed a screening strategy to identify new chemotherapeutic agents that selectively target the loss of the VHL tumor suppressor gene in renal cell cancer. He also heads the Radiation Biology Program in Stanford’s Cancer Center, and is Director of the Cancer Biology Interdisciplinary Graduate Program. Professor Giaccia was awarded an American Cancer Society Junior Faculty Research Award and the Michael Fry Award from the Radiation Research Society for his outstanding contributions on understanding the molecular mechanisms of resistance that are modulated by the tumor microenvironment. Professor Giaccia has co-authored the seventh edition of the most prominent textbook in the field, “Radiation Biology for the Radiologist”, with Professor Eric Hall from Columbia. He is currently the “Jack, Lulu and Sam Wilson Professor of Cancer Biology” at Stanford Medical School.
Abstracts this author is presenting: