Alana L Welm
The research in my laboratory is focused on the mechanisms of breast tumorigenesis and metastasis, where we have developed new, complementary in vitro and in vivo approaches to gain a better understanding of this process. Using these methods, we discovered that the Ron signaling pathway is an important facilitator of breast cancer metastasis. Our current areas of research include:
1. Mechanisms by which Ron and short-form Ron promote metastasis, including the role of Ron in anti-tumor immunity
2. Mechanisms by which Ron signaling preferentially induces breast cancer metastasis to bone
3. Pre-clinical studies of Ron inhibitors for treatment of metastatic breast cancer
4. Development of innovative mouse models for improved prediction of drug response in breast cancer, including our published patient-derived breast tumor graft models.
Abstracts this author is presenting: