Tuesday, 4th September 14th International Biennial Conference on Metastasis Research 2012

How to review a manuscript Dan Welch - Deputy Editor for Reviews, Cancer Research James Talmadge - Editor-in-Chief International Immunopharmacology Melania Ruiz - Senior Publishing Editor of Clinical & Experimental Metastasis

• Endoplasmic reticulum stress regulator GRP78 and cancer - Amy Lee
• Metabolism of cancer cells in hypoxia - Masahiro Inoue
• The role of germline genetic variation in the regulation of metastasis-related transcriptional programs - Nigel Crawford
• The role of molecular chaperones in metastasis - Cara Lomas
• Overexpression of the GTP-binding protein rab31 induces a switch from an invasive to a proliferative phenotype in breast cancer cells - Susanne Sölch
• Breast Tumor Kinase (Brk/PTK6) Mediates Increased HGF/MET-Induced Breast Cancer Cell Signaling and Migration - Carol A Lange

• Selection and adaptation during metastatic cancer progression - Christoph A Klein
• Cancer micrometastasis and circulating tumour cells - Klaus Pantel
• Combating breast cancer brain metastasis: the CTC signature - Dario Marchetti
• Disseminated cancer cells from non-metastatic patients display tumorigenic potential in immunodeficient mice - Melanie Werner-Klein

Informal Discussion with experienced researchers: Danny Welch, Sue Eccles - who else?

• Fibrosis and Cancer Progression - Raghu Kalluri
• Vegf-D promotes tumor metastasis by regulating prostaglandins produced by the collecting lymphatic endothelium - Steven Stacker
• A novel small noncoding RNA regulated pathway controlling EPC biology and tumor angiogenesis. - Albert S. Mellick
• A novel molecular mechanism mediating vascular metastasis - John Hooper

• Degradomics analyses of dynamic proteolytic networks  in the 4T1 tumor and lung  metastases model of breast  cancer - Chris Overall
• Molecular and cellular crosstalk between tumor and inflammatory cells in the tumor microenvironment: role in metastasis - James E. Talmadge
• Tissue Factor, VCAM-1 and VAP-1 orchestrate the recruitment of monocytes/macrophages to tumour cells in pulmonary metastasis - Ana M. Gil-Bernabe
• Co-evolution of breast to brain metastatic and neural progenitor cells - Josh Neman
• A furin resistant form of semaphorin-3E as a potential treatment for metastatic disease - Gera Neufeld

• Tumour-microenvironment interaction: the effect of analgesics. - Banafsheh Afshar Imani
• The inflammation-resolving trihydroxy-docosahexaenoic acid derivative, resolvin D2 is an estrogen receptor ligand that supports MCF-7 cell proliferation - Nuha Alzaubai
• The inflammatory cytokine oncostatin M is a potent inducer of mammary tumor metastasis - Celeste Bolin
• Enhanced expression of MDA-9/syntenin induced through the tissue-factor pathway in melanoma promotes tumor cell migration and metastasis - Habib Boukerche
• The contribution of stromal caveolin-1 to breast cancer metastasis - Allan D Burrows
• Suppression of breast cancer metastasis by BMP4 - Yuan Cao
• Stanniocalcin 1 in mammary tumorigenesis - Andy Chang
• Melaleuca alternifolia Concentrate (MAC): a novel plant-derived anticancer agent - Amanda M Clark
• Tetraspanins as metastatic regulators of prostate cancer - Ben T Copeland
• Microenvironmental regulation of kinase signalling dynamics as a critical mediator of tumour metastasis - Thomas R Cox
• CD151, a novel candidate for regulation of prostate cancer cell motility, invasion and angiogenesis - Sujitra Detchokul
• Metastasis in the ovarian cancer microenvironment is induced by kallikrein proteases - Ying Dong
• Genetic ablation of SOX18 function suppresses tumor lymphangiogenesis and metastasis of melanoma in mice  - Tam Duong
• Loss of osteoclasts contributes to the development of osteosarcoma pulmonary metastasis - Liliana Endo-Munoz
• Glucocorticoids inhibit breast tumour cell migration - Ebony R Fietz
• Endogenous interleukin-4 receptor expression confers a distinct survival advantage to mammary and colon tumor cells in vitro and in vivo. - Barbara Fingleton
• The activity of the urokinase receptor in promoting tumor growth requires its interaction with the extracellular matrix protein vitronectin - Sonu Gandhi
• Surfactant protein A suppresses progression of human lung adenocarcinoma in an experimental lung metastasis model. - Hisatsugu Goto
• The heparan sulfate mimetic PG545 acts against heparanase to reduce metastasis and prolong survival in 4T1 breast carcinoma model - Edward Hammond
• Potential involvement of ASC in cancer progression and metastasis. - Shigeaki Hida
• Cathepsin D is required for tumour stroma development. - Floriane M Imhoff
• Anti-adhesive and anti-apoptotic effect of epiglycanin/mucin 21 - Tatsuro Irimura
• Galectin-1 as a Potent Target for Cancer and Metastasis Therapy: Role in the Tumour Microenvironment - Koichi Ito
• Analysis of the role of the G protein-coupled receptors formyl peptide receptor-1, -2, and -3 in progression of human and murine breast cancer - Cameron N Johnstone
• Three-dimensional (3D) modelling of the prostate cancer microenvironment - Chambers F Karen
• NBRI16716A inhibits tumor growth through modulating tumor-stromal cell interactions - Manabu Kawada
• Expression profiling of ECM proteins in Indian Patients with Urothelial carcinoma of bladder  - Rehan Khan
• Testing the efficacy of novel HDAC inhibitors for the treatment of breast cancer brain metastasis - Soo Hyun Kim
• 3,3-diindolylmethane plus LY294002 suppress the oncogenic activity of YAP in colon carcinoma cancer cells - Soo Mi Kim
• Overxpression of Angiomodulin (AGM/IGFBP-rP1) in Tumor Stroma and Vasculature: Differential Regulation and Functions. - Eriko Komiya
• Dll4-Fc, an inhibitor of Dll4-notch signaling, suppresses liver metastasis of small cell lung cancer cells through down-regulation of NF-kappa-B activity - Takuya Kuramoto
• Annexin A2 released during ovarian cancer-peritoneal cell interaction promotes a pro-metastatic cancer cell behaviour - Noor A Lokman
• Resistance to anoikis alters the adhesion and promotes the increase of syndecan-4 and heparanase expression in endothelial cells in culture. - Carla Cristina Lopes
• Host-derived CCL2 plays a critical role in prostate cancer growth and skeletal metastasis - YI LU
• Investigating the anti-metastatic activity of the recombinant disintegrin domain of ADAM9 in breast cancer cell lines - Ana Carolina B.M. Martin
• A role for the disintegrin domain of adam9 in tumor cell transmigration and cell adhesion - Kelli C. Micocci
• Alteration of tumor microenvironment during antiangiogenic therapy in colorectal cancer xenograft. - Shinichiro Miyazaki
• SSeCKS modulates metastasis through multiple organ- and route-specific tumor-microenvironment interactions. - Masashi Muramatsu
• N-glycosylation regulates cathepsin L2 functions - Yuki Niwa
• Characterization of malignant melanoma growth triggered by the brain microenvironment in experimental metastasis models - Vigdis Nygaard
• Drug Transporters are Differentially Expressed in Cancer-Associated Pancreatic Stellate Cells (Key Cells Involved in Enhancing Pancreatic Cancer Progression and Chemoresistance). - Phoebe Phillips
• Sympathetic nervous system regulation of tumor associated macrophages in metastasis - Matthew A Pimentel
• Targeting CSF-1 induced macrophage migration to inhibit tumour invasion and metastasis - Fiona J Pixley
• Is β3 integrin a good therapeutic target for bone-metastatic breast tumours? - Normand Pouliot
• The microenvironment factor S100A4 as a modulator of tumor-stroma crosstalk and aggressive phenotype in malignant melanoma - Lina Prasmickaite
• Type 1 interferons as potent suppressors of breast cancer metastasis to bone - Jai Rautela
• Laminin Gamma2 Chain Promotes Invasion of Tumor Cells into Vascular Endothelial Cell Layer In Vitro - Hiroki Sato
• The tumour-stroma microenvironment of late stage ovarian cancer in 3D - Jana Schulz
• Paracrine Hedgehog signaling: Roles in tumor microenvironment and metastasis - Lalita A Shevde
• Immune regulation of breast cancer metastasis - Clare Y Slaney
• Degradation products of hyaluronan produced in the context of tumors are novel regulators of lymphangiogenesis - Jonathan P Sleeman
• Critical roles of Notch signaling pathway in colon cancer metastasis - Masahiro Sonoshita
• TGFBR3 blocks human ovarian cancer spheroid adhesion and invasion in a three-dimensional culture model of intraperitoneal metastasis - Kaye L. Stenvers
• Metastatic tumours promote monocyte mobilisation - Agnieszka Swierczak
• Aloe vera and honey solution and ethanolic fraction decrease metastatic process in Walker 256 tumour-bearing rats.  - Rebeka Tomasin
• The antimicrobial peptide LL-37 inhibits migration of the prostate cancer PC-3 and DU145 cell lines  - Yan Tu
• Anti-tumor effect of VEGF-targeted therapy on Synovial sarcoma - Toru Wakamatsu
• Targeting L-type amino acid transporter 1 (LAT1) to suppress metastasis in prostate cancer - Qian Wang
• Phospholipase A2 activities in cancers - Yan Xu
• Hepatocyte Growth Factor: A potential therapeutic target in pancreatic cancer - Zhihong Xu
• Osteopontin promotes lung cancer invasion and metastasis by improve the invadopodia formation - Qinghua Zhou
• Local release of Osteoprotegerin by breast cancer cells inhibits cancer-induced osteolysis and intra-osseous tumour burden but promotes pulmonary metastasis. - Irene Zinonos

• The Effect of StarD13 on Colorectal Cancer Proliferation and Invasion - Mirvat El-Sibai
• Novel targets for kallikrein-related peptidase 4 in the prostate cancer microenvironment establish its role in tumour progression - Ruth A Fuhrman-Luck
• The Role Of Megakaryocytes In Breast Cancer Metastasis To Bone - Andrea M Mastro
• miR-193b regulates breast cancer proliferation and metastasis in vivo - Alexandra Rizzitelli
• Identification and validation of two novel metastatic markers in Osteosarcoma - Eleni Topkas

• Monitoring early efficacy of PI3K/mTOR targeted cancer therapies using ¹⁸F-FPHCys, a new potential imaging biomarker - Delphine Denoyer

• ITGBL1 is a Transcriptional Target of RUNX2 and Promotes Bone Metastasis of Breast Cancer - Yu-Mei Feng
• CXCR4 chemokine signalling in neuroblastoma bone marrow metastasis - Jamie I Fletcher
• Characterisation of a novel breast cancer cell line, BCBM1, derived from a bone metastatic lesion of a breast cancer patient - Julie K Johnson
• Elucidation of Genomic Copy Number Alterations Associated with the Metastasis of Non Small Cell Lung Cancer (NSCLC) to Brain by Comparative Molecular Inversion Probe (MIP) Technology - Hye Won Lee
• Anticancer efficacy of the hypoxia–activated prodrug TH-302 in a preclinical model of osteosarcoma development and metastasis. - Vasilios Liapis
• An integrated in vivo genomics screen implicates long non-coding RNAs H19 and Neat1 in breast cancer metastasis - Richard P Redvers
• Development of a novel orthotopic transplantation model of human small cell lung cancer metastasis - Shuichi Sakamoto
• CEP55; a new target for prevention of breast cancer progression and metastasis - Jacinta Simmons