Monday, 3rd September 14th International Biennial Conference on Metastasis Research 2012

• Targeting the HIF/VHL pathway therapeutically to treat metastatic disease - Amato Giaccia
• Targeting Src family kinases as novel therapies for breast cancer brain metastases - Dihua Yu
• Osteopontin: a promoter and a potential therapeutic target for hepatocellular carcinoma metastasis - Lun-Xiu Qin
• The role of RAD51 in the biology and therapeutic response of high-grade metastatic breast cancers. - Adrian P Wiegmans

• EMT in the progression of carcinoma - Jean Paul Thiery
• Cellular plasticity as an important mechanism of drug-resistance to cancer therapies - John Haley
• ARHGAP8 is a marker of differentiated epithelium whose loss during breast cancer progression is tightly linked to epithelial-to-mesenchymal transition (EMT), the claudin-low molecular subtype, and a cancer stem cell phenotype - Cameron Johnstone
• miR-27 regulates endothelial differentiation of breast cancer stem-like cells - Qiang Liu
• Tumor Propagating cells in breast cancer tumorigenesis and metastasis - Radhika Nair
• Fascin is required for neural crest migration and brain tumor invasion in zebrafish - Rodney A Stewart

Dr. Elizabeth Williams Title: Proximity ligation assay identifies heterodimerisation and activation state of endogenous proteins in tumour tissue and isolated cells

Dr. Cathy Noone Title: Tumor Microenvironment: Its Role in Tumor Growth and Metastasis.

• Imaging the metastatic process - Erik Sahai
• Modeling and visualizing metastasis - Robert M. Hoffman

• Contribution of cancer stem cells to angiogenesis and invasion of cancer - Xiu-Wu Bian

• Innate immune system mediates focal metastasis - Sachie Hiratsuka-Nakamura
• Blocking Ron kinase prevents metastasis by boosting anti-tumor immunity - Alana L Welm
• MiR-106b is regulated by transforming growth factor β signaling and promotes metastasis in breast cancer - Erwei Song
• Tumour cell induced immune suppression dictates bone metastasis in breast cancer - Belinda Parker
• Neural regulation of metastasis: New avenues for therapeutic intervention - Erica K Sloan
• Bioenergetic requirements of metastatic dissemination - Valerie LeBleu

• Correlations between biomarkers for invasion/metastasis and patient clinical outcomes in rectal cancer - Seong Beom Ahn
• Prognostic factor for the patients with bone-only metastasis in breast cancer - Sung Gwe Ahn
• Rational combination therapy against triple-negative breast cancer - Fares Al-Ejeh
• Antibodies binding the ADAM10 substrate recognition pocket inhibit Eph function - Lakmali Atapattu
• Can Dicer explain decreased microRNA expression in lymph node metastases of triple negative breast cancer? - Kelly A Avery-Kiejda
• Association of Kallikrein gene variants with metastatic prostate cancer   - Jyotsna Batra
• Chromosomal Instability in BRAF Mutant, Microsatellite Stable Colorectal Cancers - Catherine E Bond
• Nanoparticles, cobalt complexes and tumour activatable pro-drug peptides: Hypoxia targeting strategies to inhibit tumour growth and metastasis - Nicole S Bryce
• Association of β-catenin with HPV Surrogate Marker p16 and Lymph Node Metastasis in Oropharyngeal Carcinoma - Zhuo Georgia Chen
• Inhibition of EGFR/Her-2 affects growth of ascitic ovarian cancer in vitro study - Kenny Chitcholtan
• Investigating the anti-proliferative activity of ginger-derived substances - Marcia R Cominetti
• Understanding metastatic breast cancer through an autopsy series - Margaret C Cummings
• SRF methylation in myofibroblasts predicts less metastasis of non-cardiac gastric carcinomas in China, Japan, and Korea - Dajun Deng
• The highly selective focal adhesion kinase inhibitor CTx-0294945 reduces tumour cell growth in an experimental metastasis model. - J Doherty
• Breast Cancer Network Australia - Working with you for results - Nicca Grant
• Evaluation of Surgical treatment of metastatic spinal tumors - Wei Guo
• YKL40 as a therapeutic target for the treatment of castration resistant prostate cancer - Varinder Jeet
• Fibroblast Growth Factor Receptor-2 Mutations in Endometrial Cancer - Yvette Jeske
• Engineering receptor based antagonists of the Gas6/Axl for therapeutic applications - Yu Miao
• Antitumor Effects of Anti-podoplanin Antibody NZ-1 against Malignant Mesothelioma - Yasuhiko Nishioka
• The Role of IQGAP1 in Ovarian Cancer Progression - Sheri Nixdorf
• Zoledronic acid facilitates large scale ex-vivo expansion of human γδ T cells for use in immunotherapy targeting bone metastases - Vasilios Panagopoulos
• Uncovering molecular mechanisms involved in metastasis to the brain - Jodi M Saunus
• Sub1 is a marker of aggressive breast cancer - Wei Shi
• Prediction of Postoperative Venous Thromboembolism in Patients with Malignancy of the Lower Extremity - Seung Han Shin
• Evidence for activation of signaling pathways that define the aggressive biology of TNBrCA in atypical breast lesions from high-risk African American women - Adria Suarez
• The Chemokine Receptor CXCR4 in Small Cell Lung Cancer (SCLC) and its role in metastasis - Sanaz Taromi
• B7-H3 - a new metastasis-promoting protein - Christina Tekle
• Esophageal squamous carcinoma and normal squamous epithelia express differentially glycosylated mucin 21 - Yuan Tian
• Paraneoplastic polyarteritis nodosa masquerading as widespread metastatic disease: A case report - David Veitch
• Differential expression of Kindlin-1 and Kindlin-2 during lung cancer progression - Hongquan Zhang

• Screening for drugs targeting metastatic breast cancer - Karl-Johan Leuchowius
• Molecular analysis of circulating (CTC) and disseminated tumour cells (DTC) in human breast cancer xenograft models. - Anthony Tachtsidis
• Dynamic analysis of lung metastasis by mouse osteosarcoma LM8 – VEGF is a candidate for anti-metastasis therapy - Takaaki Tanaka

• Genome wide profiling of lung metastases in the MMTV-PyMT model - Stephanie L Allerdice
• Carcinoembryonic antigen promotes metastasis via disruption of E-cadherin adherens junction complexes. - Olga Bajenova
• Loss of TGFBR3 in ovarian cancers reduces sensitivity to chemotherapeutics and enhances cancer stem cell marker expression - Maree Bilandzic
• Is there a clinical relevance of EMT in metastatic progression?- investigations of colorectal and breast cancer patient materials - Linda Bojmar
• THE UBIQUITIN LIGASE SIAH IS A NOVEL REGULATOR OF EPITHELIAL-MESENCHYMAL TRANSITION IN BREAST CANCER - Anna Chen
• Changes in tumour infiltrating cells following vascular disruptive agent treatment may contribute to therapy resistance - Theodora Fifis
• The Rho Pathway and Hormone Resistance and/or Metastasis of ER alpha-Positive Breast Cancer Cells - Suzanne AW Fuqua
• Uncovering the metastatic potential of the transcription factor Elf5 in breast cancer - David Gallego Ortega
• The microRNA-200 family as regulators of breast and colorectal tumour metastasis - Philip A Gregory
• Snail up-regulates Dnmt1 and sequesters it in cytoplasm: An epigenetic alteration by Snail in ovarian cancer - Hongyan Jin
• Mesenchymal-transitioned epithelial cancer cells instigate EMT via paracrine WNT signal - Shinichiro Kato
• Acidic extracellular pH induces epithelial-mesenchymal transition in Lewis lung carcinoma model. - Yasumasa Kato
• ZEB2 and Sp1 have cooperative roles as transcriptional activators of mesenchymal genes during EMT - Semi Kim
• Gene silencing of c-Met leads to brain metastasis inhibitory effects - Se Jeong Lee
• Protein Tyrosine Phosphatase Pez - a novel regulator of Protein Trafficking and Secretion - X. Li
• A mathematical model to simulate tumour cell interactions, motility and invasion - J. Guy Lyons
• Overexpression of the urokinase receptor splice variant uPAR-del4/5 in breast cancer cells modulates gene expression of other tumor-relevant proteins - Viktor Magdolen
• A novel role for the E3 -ligase E6AP in the control of cell invasion and migration - Mariam Mansour
• Mechanisms of TGFß1 signaling and repression of E-cadherin in Oral Cancer - Ali Nawshad
• New avenues to inhibit mutant p53-driven metastasis - Paul M Neilsen
• Identification & characterisation of EMT-regulatory miRNAs in mammary development and carcinogenesis - Akira Nguyen
• Sunitinib/OXi4503 combination therapy leads to induction of EMT - Linh Nguyen
• Epithelial Mesenchymal Plasticity associated loss of EpCAM in Breast Cancer – A Functional Genomics Approach - Cletus A Pinto
• The Embryonic Morphogen Nodal Promotes EMT, Invasion and Metastasis via a Non-Canonical ERK-Dependent Pathway - Lynne-Marie Postovit
• Wnt-5a is over-expressed in epithelial ovarian cancer and is associated with poor patient survival - Gaya Punnia-Moorthy
• Inhibiting p90 ribosomal S6 kinase (RSK)/Y-box binding protein-1 (YB-1) signaling eliminates tumor-initiating cells (TICs) in triple-negative breast cancer. - Kristen Reipas
• MicroRNA-200 family members differentially regulate spontaneous breast cancer metastasis - Suraya Roslan
• 3D quantitative analysis of local invasiveness and lymphovascular dissemination of human oral squamous cell carcinoma xenografts in mouse tongue microenvironment - Yoshihito Shimazu
• DISCOVERY OF BREAST CANCER EPITHELIAL MESENCHYMAL PLASTICITY-ASSOCIATED MICRORNAS USING BIOINFORMATICS AND NEXT GENERATION SEQUENCING - Eliza T.L Soo
• Functional validation of a novel prostate cancer susceptibility variant in the KLK3 gene  - Srilakshmi Srinivasan
• A significant subpopulation of tumor cells in sentinel lymph nodes from breast cancer patients express mesenchymal characteristics and are not detected by conventional methods - Siri Tveito
• Alternative pre-messenger RNA splicing events in the PMC42 model of Epithelial Mesenchymal Transition - Edwin Widodo
• Whole genome multiparametric screening using morphological change and vimentin reporter activity to identify modulators of epithelial-mesenchymal transition - Elizabeth D Williams
• Integrin linked kinase complexes with p38 to regulate bladder cancer cell migration and actin cytoskeleton remodelling - Liang Yu
• Kindlin-2 forms a transcriptional complex with β-catenin and TCF4 to enhance Wnt signaling and promotes tumor invasion - Hongquan Zhang

• Beta-blocker therapy reduces breast cancer metastasis. - Ming Chai
• Stable and potent suppression of TUBB3 modulates the expression of proteins involved in tumourigenesis and metastases in non-small cell lung cancer - Rafael B Erlich
• Breast cancer progression and metastasis regulated by SIN3 chromatin modification complexes - Douglas R. Hurst
• Neural regulation of pancreatic cancer: Beta-adrenergic signaling increases primary tumor growth and metastasis - Corina Kim-Fuchs
• Heat Stress Induces Epithelial Plasticity and Cell Migration Independent of Heat Shock Factor 1. - Benjamin J Lang
• Neural signaling promotes lymphangiogenesis and increases lymphatic metastasis. - Caroline P Le
• Over-expression of either CD44 or CD147 modulates in vitro and in vivo prostate cancer metastasis and chemoresistance - Yong Li
• MicroRNA-137, a HMGA1 target, suppresses cell invasion and metastasis of colorectal carcinoma by directly targeting FMNL2 - Li Liang
• Molecular pathways and therapeutic targets for triple-negative breast cancer - Mariska Miranda
• Silencing Heat Shock Proteins 27 and 47 Inhibits Platelet-Derived Growth Factor (PDGF)-Induced Pancreatic Stellate Cell Proliferation: Implication in Pancreatic Cancer Progression. - Phoebe Phillips
• Regulation of metastasis via CDK-mediated phosphorylation of BRMS1 and RBP1 - Boris Sarcevic
• ERK5 regulates invasiveness of osteosarcoma by inducing MMP-9 - Seung Han Shin
• Sodium butyrate inhibited invasion of cancer cells - Kiyoko Yoshioka